​Model of
Biology
IMPACTS
The Acid Mine Drainage Project
Acidic outflows have been found all throughout the world from metal mining sties, causes by the oxidation of sulfide minerals exposed in the air. Through metagenomics studies, it has allowed for the assembly sequences of genomes that foster the stude of gene exchange and expression. The Acid Mine Drainage Project (AMD) is targeted to created acidic solutions that result from mining activities. The AMD project furthers the exploration of diverse microbial communities which demonstrates the different types of sequencing of mocrobial genomes.
The Sargasso Sea Metagenomic Survey and Community Profiling
One of the largest metegenomic sequencing was conducted in 2004 by a shot gun sequencing survey of microbial assmblages from the Sargasso Sea-an ocean with a low diversity of organisms. The project started to collect microbial cells and viruses and extrated DNA from them. The survey represented over one million protein-encoding genes which showed more protein sequences than were present in all currated protein databases. The data from Sargasso Sea was remarkable and had tons of new information showing plenty organisms in Sargasso. Metagenomic DNA sequencing will soon outnumber other types of DNA sequencing.
The Soil-Resistome Project
Studying antibiotics transformed medicine in the middle of the 20th century by providing cures and treatmesnt for infections and diseases that weren't treatable before. The soil-resistome project used a metagenomics approachwhere fragments of DNA are cloned from soil and the clones are screened for expression of antibiotic resistance. The project led to isolation of new groups of antibiotic-resistance genes. The plan was to clone metagenomic DNA fromt the soil. The project proved new information about aminoglycoside resistance genes that encode a group of enzymes called acetyltransferase that are closely related to each other.
